Table 4 Univariate analysis of DFS and known prognostic factors in stage II-III colon carcinoma patients.
Parameters | No. at riska | Events | HR | 95% CI | p value |
|---|---|---|---|---|---|
Sex | 0.53 | ||||
Female | 401 | 133 | 1.00 | ||
Male | 466 | 166 | 1.08 | 0.86–1.35 | |
Age | <0.0001* | ||||
<65 | 387 | 103 | 1.00 | ||
≥65 | 480 | 195 | 1.67 | 1.32–2.12 | |
pT stage | 0.03 | ||||
T1-2 | 32 | 5 | 1.00 | ||
T3-4 | 833 | 293 | 2.65 | 1.10–6.42 | |
pN stage | <0.0001* | ||||
Negative | 457 | 125 | 1.00 | ||
Positive | 410 | 173 | 1.75 | 1.39–2.20 | |
Tumor location | 0.09 | ||||
Proximal colon | 425 | 157 | 1.00 | ||
Distal colon | 442 | 141 | 0.82 | 0.66–1.03 | |
CD8+ TILs | <0.0001* | ||||
High | 283 | 60 | 1.00 | ||
Low | 584 | 238 | 2.16 | 1.63–2.86 | |
Tumor CD274(PD-L1) | 0.0007* | ||||
High | 384 | 108 | 1.00 | ||
Low | 480 | 190 | 1.51 | 1.19–1.91 | |
CD8+ TILs/Tumor CD274 (PD-L1) | <0.0001* | ||||
High or high | 507 | 137 | 1.00 | ||
Low/Low | 360 | 161 | 1.88 | 1.49–2.36 |
