Table 2 Effect of Lat B and SB77 on Aqueous OF in Human Eyes.

From: SB772077B, A New Rho Kinase Inhibitor Enhances Aqueous Humour Outflow Facility in Human Eyes

SB77 (µM)

n

Eye Pair

Baseline OF (μl/min/mmHg)

Rx-3 h/BL

Rx-12 h/BL

Rx-24 h/BL

%Change in OF

Baseline

3 h

12 h

24 h

0.1

6

Con

0.22 ± 0.04

1.03 ± 0.03

1.04 ± 0.02

1.02 ± 0.02

1.56 ± 23.6

5.12 ± 4.12

15.63 ± 5.59

15.9 ± 5.4

6

Exp

0.27 ± 0.07

1.08 ± 0.04

1.20 ± 0.04

1.18 ± 0.05

10

8

Con

0.29 ± 0.04

1.14 ± 0.05

1.12 ± 0.07

1.09 ± 0.05

−4.74 ± 12.9

4.58 ± 9.9 (p = 0.031)

27* ± 2.1 (p = 0.015)

29.34* ± 5.88 (p = 0.018)

8

Exp

0.22 ± 0.02

1.19 ± 0.18 (p = 0.049)

1.25* ± 0.07 (p = 0.014)

1.29* ± 0.09 (p = 0.017)

50

8

Con

0.20 ± 0.04

1.05 ± 0.04

1.15 ± 0.07

1.18 ± 0.13

−9.65 ± 11.67

21.36* ± 3.72 (p = 0.027)

28.55** ± 5.4 (p = 0.009)

39.48** ± 2.86 (p = 0.004)

8

Exp

0.15 ± 0.02

1.28* ± 0.06 (p = 0.032)

1.47** ± 0.09 (p = 0.002)

1.64** ± 0.18 (p = 0.002)

  1. Outflow facility (OF) (μl per minute/mm Hg) was calculated as the ratio between the inflow rate (μl/minute) and the measured IOP (mm Hg) and the values.
  2. are expressed as Mean ± SEM.
  3. % Change in OF was calculated using the formula: % Change in OF = [(Treated/BL/Control/BL) −1) × 100].
  4. Exp – Experiment; Con = Control.
  5. *p < 0.05, **p < 0.005, (Paired-t- test).
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