Figure 5
From: The roles of IL-17C in T cell-dependent and -independent inflammatory diseases
High susceptibility of Il17c−/− mice to T cell-independent DSS-induced colitis. Female mice were provided sterile drinking water containing 2.0% DSS ad libitum for 5 days, followed by 15 days of regular drinking water. (a) Change in body weight (%). Wild-type mice (n = 10) and Il17c−/− mice (n = 10). *p < 0.05 and **p < 0.01 vs. corresponding values for Il17c−/− mice. (b) Area under the curve (AUC) for the body weight on Days 5–8 in (a). **p < 0.01. (c)Representative pictures of the animals’ colons on Day 8. (d) Length of colons on the indicated days. Wild-type mice (naïve, n = 4; and Days 8, 15, and 33, n = 4–5) and Il17c−/− mice (naïve, n = 4; and Days 8, 15, and 33, n = 8–10). (e) Representative images of colon sections (Day 8) stained with hematoxylin and eosin. Bars = 100 μm. (f) Histological scores on Day 8. **p < 0.01. The data show the mean + SEM (a,b,d,f).
