Figure 5 | Scientific Reports

Figure 5

From: Argonaute2 attenuates active transcription by limiting RNA Polymerase II elongation in Drosophila melanogaster

Figure 5

A model for AGO2 recruitment and attenuation of active transcription. (A) Under normal conditions, AGO2 is recruited to active promoters likely by interacting with the transcription initiation machinery. (B) Once polymerase transitions into elongation, AGO2 may be transferred to mRNA and attenuate transcription. Alternatively, AGO2 association with nascent RNAs could be mediated by Pol II and/or other factors. (C,D) In the absence of AGO2, there is an increase of transcription elongation and CTD phosphorylation of Pol II on S5 and S2, in addition to either (C) gain of NELF at the TSS or (D) loss of NELF over the gene body.

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