Figure 2
UUO injury causes moderate kidney dysfunction and elevated blood pressure in mice. (A) Serum creatinine for the UUO mice was significantly elevated 3 weeks after UUO injury, compared to the controls. Serum creatinine was 0.56 ± 0.02 mg/dL in the UUO-only mice and 0.48 ± 0.36 mg/dL in Enalapril-treated UUO mice, versus 0.3 ± 0.04 mg/dL in the controls. Enalapril treatment alone did not significantly increase serum creatinine in the wild type. Enalapril-treated UUO mice had improved serum creatinine. **P < 0.01 vs. Control. (B) Blood urea nitrogen (BUN) was measured. BUN was significantly elevated in UUO mice 3 weeks after injury, compared to the controls. Enalapril treatment prevented elevation of BUN. Enalapril alone did not significantly increase BUN compared to the controls. **P < 0.05 vs. Control. (C) Both systolic and diastolic blood pressures (BP) were significantly elevated in the UUO mice starting 2 weeks after UUO injury. The mean systolic BP was 142.33 mmHg and 144.92 mmHg in the UUO mice 2 and 3 weeks after UUO injury respectively, compared to a mean systolic BP of 124.01 mmHg in controls. *P < 0.05 vs. Control for 2-week systolic BP, ##P < 0.01 vs. Control for 3-week systolic BP, *P < 0.005 vs. Control for 2-week diastolic BP, #P < 0.005 vs. Control for 3-week diastolic BP. Bar values represent means ± SEM (error bars). Statistical analyses were performed with t-tests. N = 12.
