Figure 6
From: Uric acid enhances alteplase-mediated thrombolysis as an antioxidant
Effect of UA on alteplase-damaged vascular basement membrane by transmission electron microscopy. (a–c) Fine morphology of endothelial cells in alteplase with or without UA and control rats, respectively. Arrows indicate the severity of endothelial cell swelling, as shown by vacuolization size, and large swelling observed in alteplase without UA and control rats. (d–f) Fine morphology of the basement membranes of endothelial cells in alteplase with or without UA and control rats, respectively. Arrows indicate the lining along the vascular diameter. The basement membranes were highly disrupted in the alteplase without UA and control groups. (g) Endothelial damage was significantly lower in the alteplase with UA group compared with the other groups.
