Figure 4
From: Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism
Chronic BP3 expression in DIO mice reduces body weight, hyperglycemia and modulates lipogenic gene expression in liver and WAT. (A) Schematic diagram showing the protocol for the in vivo transfection of mBP3 or control expression vector in C57BL/6 J DIO mice. Mice received eight treatments and were euthanized 45 days after the first treatment. (B,C) Total body weight (B) and body weight gain (C) of control and mBP3 transfected DIO mice, analyzed by linear regression. (D) Concentrations of serum metabolites in control and mBP3 transfected DIO mice. (E) Random blood glucose in fed control and mBP3 transfected DIO mice measured every 7 days. (F) Average change in blood glucose in fed control and mBP3 transfected DIO mice throughout the course of the experiment. (G,H) Change in gene expression in DIO mouse livers (G) and WAT (H) measured by qRT-PCR. Data are expressed as fold of control (Mean ± SEM; n = 5; *P < 0.05; **P < 0.01; ***P < 0.0001).
