Table 1 Baseline characteristics of the subjects.

From: The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes

Parameter (Unit) [Reference Interval]*

Control

Type 2 Diabetes

p Value

BMI adjusted p Value

N

57

51

—

—

Male %

42.1

51.9

ns

—

Age (years)

53.7 ± 7.7

57.1 ± 10.3

ns

—

Weight (kg)

72.8 ± 18.0

84.7 ± 16.4

<0.01

—

BMI (kg/m2)

25.7 ± 4.1

30.6 ± 5.5

<0.001

—

Waist (cm)

87.7 ± 12.7

103.5 ± 11.7

<0.001

—

Systolic BP (mmHg)

124 ± 20

146 ± 14

<0.001

<0.001

Diastolic BP (mmHg)

75 ± 10

67 ± 31

ns

ns

Fasting Glucose (mg/dl) [70–105]

94.1 ± 9.4

153.7 ± 45.0

<0.001

<0.001

Insulin (µUI/mL) [2.0–14.0]

7.19 ± 2.62

12.56 ± 6.57

<0.001

<0.05

HOMA-IR [0.0–3.8]

1.63 ± 0.73

4.55 ± 2.73

<0.001

<0.001

HbA1c (%) [4.0–5.6]

5.3 ± 0.3

7.1 ± 1.2

<0.001

<0.001

Total cholesterol (mg/dl) [80–200]

203.7 ± 34.5

158.7 ± 39.1

<0.001

<0.001

HDL-c (mg/dl) [35–70]

57.2 ± 19.7

43.5 ± 9.8

<0.001

<0.01

LDL-c (mg/dl) [40–150]

126.5 ± 29.5

87.0 ± 31.7

<0.001

<0.001

Triglycerides (mg/dl) [30–150]

90.5 (62.8; 150.5)

132.0 (92.8; 164.8)

<0.01

ns

hs-CRP (mg/l) [0.0–1.69]

1.17 (0.44; 2.17)

2.45 (1.22; 5.39)

<0.01

ns

  1. Data are shown as mean ± SD for parametric variables and were compared by a Student’s t test, or as median (25th and 75th percentiles) for non-parametric variables and were compared by a Mann–Whitney U test. A univariate general linear model was used to adjust changes by BMI. To compare proportions among groups, Chi-Square test was used.
  2. *Reference intervals according to the service of clinical analysis of our hospital were taken into account for the interpretation of clinical laboratory results.
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