Figure 4
Cumulative risk trends. (A) Average and 95% CI of RR sums by gender and age group. The dotted lines indicate slopes significantly different from zero. (B) Average and 95% CI of RR sums of diseases identified as central in the networks or as other, non-central diseases. The arrows indicate the cumulative risk differences between central and non-central diseases in men (60 years) and women (65 years). (C) Graph showing the correlation between the average centrality value of each node across all networks in men, and the difference between the minimum and maximum RR sums of each disease. The linear trend and 95% CI (shaded area) are shown. (D) Average and 95% CI of RR sums of diseases identified as network community roots or other diseases (i.e., non-roots). The arrow indicates the cumulative risk difference between non-root and root diseases in women (65 years). (E) Average and 95% CI of RR sums of diseases identified as having large degree leaps (≥10 edges, and excluding those that are also central) or other diseases. The arrows indicate cumulative risk differences between disease sets with large leaps and no large leaps in men (55 years) and women (60 years).
