Figure 5
Centrality and pleiotropy linked to causal genes. (A) Graphs showing the distributions of closeness and eigenvector centrality measures for different types of causal genes as indicated in the insets. The results correspond to the analysis of the curated human disease gene network and are shown for men and women disease sets derived from the SIDIAP-Q networks study. The Wilcoxon test P values of the comparisons of distributions are shown. (B) Scatter plots depicting the negative correlations between the gene expression signatures (all genes included) that define diabetic neuropathy (left panel) or undernutrition (right panel) and age at diagnosis of breast cancer. The stage-adjusted linear regression coefficients and their corresponding P values are shown.
