Table 2 Histopathologic findings in 16 NHPs positive for Zika virus.
From: Evidence of natural Zika virus infection in neotropical non-human primates in Brazil
Sample ID | Cerebrum | Heart | Lung | Liver | Spleen | Kidney |
|---|---|---|---|---|---|---|
PR 17/03 | Autolysis | Autolysis | Autolysis | Autolysis | Autolysis | Autolysis |
PR 17/04 | Autolysis | Autolysis | Mild multifocal suppurative bronchopneumonia; Intravascular microfilariae | Moderate multifocal chronic proliferative cholangitis with intralesional trematode ova and adults; Mild to moderate diffuse vacuolar (hydropic) hepatopathy; Intravascular microfilariae | Autolysis | Minimal focal lymphoplasmacytic interstitial nephritis |
PR 17/05 | Congestion and multifocal acute hemorrhage. | Congestion and multifocal acute hemorrhage. | Multifocal acute alveolar hemorrhage | Multifocal random mononuclear inflammatory infiltrates and minimal pericholangitis; Mild diffuse vacuolar (hydropic) hepatopathy | Mild to moderate, diffuse sinus histiocytosis | Minimal multifocal acute tubular degeneration with mild proteinosis; Minimal focal chronic lymphocytic interstitial nephritis |
PR 17/07 | NSLO | NSLO | Moderate to severe acute alveolar hemorrhage | Marked, diffuse vacuolar (hydropic) hepatopathy | Extramedullary hematopoiesis; Lymphoid reactive hyperplasia | Without NSLO |
PR 17/08 | NE | Minimal multifocal chronic lymphocytic myocarditis | Marked multifocal acute alveolar and bronchial hemorrhage with edema and histiocytosis; Mild multifocal chronic lymphocytic and eosinophilic perivasculitis and mild lymphoid hyperplasia; Focal parabronchial arterial bone marrow embolus. | Congestion; Minimal, focal, chronic eosinophilic pericholangitis and minimal reactive changes. | Diffuse lymphoid reactive hyperplasia and sinus histiocytosis | Mild, multifocal tubular proteinosis; Congestion. |
PR 17/11 | Multifocal acute cortical neuron necrosis | Congestion, edema and focal hemorrhage | Congestion, edema and focal hemorrhage | Moderate diffuse vacuolar (hydropic) hepatopathy | Diffuse lymphoid reactive hyperplasia | Moderate multifocal chronic membranous glomerulonephritis with lymphoid follicle formation |
PR 17/12 | NSLO | NSLO | Moderate multifocal acute alveolar hemorrhage and edema | Moderate diffuse vacuolar (hydropic) hepatopathy; Moderate multifocal neutrophilic portal hepatitis | Mild diffuse lymphoid reactive hyperplasia | Congestion |
PR 17/13 | Mild focal hemorrhage | Mild multifocal acute myocyte degeneration | Mild multifocal acute interstitial pneumonia | Marked multifocal chronic proliferative cholangiohepatitis with marked cholestasis and necrosis; Extramedullary hematopoiesis | Multifocal acute necrotizing splenitis; Extramedullary hematopoiesis. | NSLO |
PR 17/14 | Congestion | NSLO | Moderate multifocal subacute interstitial pneumonia with bronchiolitis | NSLO | Moderate lymphoid depletion | NSLO |
PR 17/15 | NE | NSLO | Autolysis | NSLO | NSLO | Mild multifocal chronic interstitial nephritis |
PR 17/16 | Congestion | Minimal focal chronic lymphocytic infiltrate; Congestion | Diffuse atelectasia; Mild multifocal subacute suppurative bronchopneumonia | Mild multifocal chronic lymphocytic pericholangitis; Mild diffuse vacuolar (hydropic) hepatopathy | NE | Mild multifocal chronic lymphocytic interstitial nephritis; Mild multifocal acute tubular degeneration |
PR 17/18 | Minimal focal lymphocytic vascular cuffing; Congestion and multifocal alveolar hemorrhage | Mild multifocal myocardial fibrosis; Mild multifocal acute myocyte degeneration with contraction band necrosis | Multifocal acute alveolar hemorrhage | Mild multifocal chronic eosinophilic and lymphoplasmacytic cholangitis with intraductal adult trematodes, bile duct hyperplasia and mild fibrosis | Mild diffuse lymphoid reactive hyperplasia and sinus histiocytosis | Mild multifocal chronic lymphoplasmacytic interstitial nephritis; Mild multifocal segmental membranous glomerulonephritis with proteinuria; Mild multifocal acute tubular necrosis |
PR 17/19 | Multifocal acute hemorrhage and congestion. | NSLO | Congestion, edema and multifocal acute alveolar hemorrhage; Focal interstitial nodular lymphohistiocytic and eosinophilic infiltrate | Mild multifocal chronic lymphoplasmacytic pericholangitis | Diffuse lymphoid reactive hyperplasia and histiocytosis | Moderate diffuse global chronic membranoproliferative glomerulitis with moderate lymphoplasmacytic interstitial nephritis; Focal granuloma. |
PR 17/20 | NE | NSLO | Locally extensive alveolar hemorrhage; Moderate focal acute suppurative bronchopneumonia | Mild diffuse vacuolar (hydropic) hepatopathy | NSLO | NSLO |
PR 17/21 | Mild focal chronic lymphocytic meningitis | Congestion | Diffuse congestion, edema and atelectasia; mild alveolar hemosiderosis | Mild multifocal chronic lymphoplasmacytic and granulomatous pericholangitis with mild hemosiderosis; Mild multifocal acute single cell hepatocellular necrosis | Mild diffuse lymphoid reactive hyperplasia and mild sinus histiocytosis | Mild multifocal acute tubular degeneration with proteinosis e atrofia glomerulocística focal |
PR 17/22 | NSLO | NSLO | Diffuse congestion, edema and multifocal acute hemorrhage; Multifocal atelectasia; Mild lymphoplasmacytic peribronchial and perivascular infiltrates with rare alveolar multinucleate giant cells | Mild multifocal chronic lymphoplasmacytic and eosinophilic cholangiohepatitis with moderate bile duct hyperplasia; Mild diffuse vacuolar (hydropic) hepatopathy | Moderate diffuse lymphoid reactive hyperplasia and sinus histiocytosis | Minimal multifocal chronic lymphoplasmacytic interstitial nephritis and rare glomerulocystic atrophy |
