Figure 2 | Scientific Reports

Figure 2

From: Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure

Figure 2

TSPO-KO TAC mice showed slower progression toward heart failure. (A) WT TAC mice and KO TAC mice had similar increases in wall thickness after 1 week, which was significantly different at 8 weeks. (B) Left ventricular end diastolic diameter (LVEDD) and (C) left ventricular end systolic diameter (LVESD) showed progressive cardiac dilation in WT TAC mice. (D) Representative images show m-mode short axis pictures of the heart in all four groups. (E) Endocardial area showed significantly higher cardiac dilation in WT TAC mice compared to KO TAC mice. (F) Systolic function, as measured by ejection fraction, showed that WT TAC mice had worse cardiac function starting at week 2. (G) Representative m-mode parasternal short axis images for all four groups after 8 weeks of sham or TAC surgery show that systolic dysfunction is most evident in WT TAC mice. n = 14, 9, 22, and 23 for WT sham, KO sham, WT TAC, and KO TAC respectively in (A–C and F). Data expressed as mean ± SEM. *p < 0.05 for WT TAC vs KO TAC, **p < 0.01 for WT TAC vs KO TAC.

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