Table 1 Echocardiographic parameters of WT and KO mice at 8 weeks after sham or TAC surgery.
| Â | WT | KO | p-values | ||||
|---|---|---|---|---|---|---|---|
Sham (n = 14) | TAC (n = 22) | Sham (n = 9) | TAC (n = 23) | WT sham vs WT TAC | KO sham vs KO TAC | WT TAC vs KO TAC | |
Echocardiography Measures | |||||||
Heart Rate (bpm) | 493 ± 41 | 523 ± 44 | 507 ± 41 | 517 ± 50 | NS | NS | NS |
Ejection Fraction (%) | 62.7 ± 2.5 | 34.5 ± 2.4 | 63.4 ± 2.8 | 55.8 ± 2.0 | <0.01 | <0.05 | <0.05 |
LVEDD (mm) | 3.89 ± 0.08 | 4.79 ± 0.10 | 3.91 ± 0.04 | 4.16 ± 0.06 | <0.01 | <0.01 | <0.01 |
LVESD (mm) | 2.53 ± 0.13 | 3.98 ± 0.15 | 2.56 ± 0.15 | 2.95 ± 0.10 | <0.01 | <0.05 | <0.05 |
LVAW,d (mm) | 0.71 ± 0.02 | 0.96 ± 0.02 | 0.73 ± 0.01 | 1.07 ± 0.03 | <0.01 | <0.01 | <0.01 |
LVAW,s (mm) | 1.09 ± 0.03 | 1.21 ± 0.03 | 1.14 ± 0.02 | 1.47 ± 0.04 | <0.01 | <0.01 | <0.01 |
LVPW,d (mm) | 0.72 ± 0.02 | 0.95 ± 0.01 | 0.74 ± 0.02 | 1.06 ± 0.03 | <0.01 | <0.01 | <0.01 |
LVPW,s (mm) | 1.10 ± 0.03 | 1.21 ± 0.03 | 1.15 ± 0.03 | 1.47 ± 0.04 | <0.01 | <0.01 | <0.01 |
