Figure 5 | Scientific Reports

Figure 5

From: Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice

Figure 5

Maternal HFD and offspring sex significantly alter lipid metabolism and bile acid secretion synthesis pathways. Correlations between a PICRUSt-generated functional profiles and genus level bacterial abundance were calculated and plotted between HFD-fed male (M-HH) and female (F-HH) offspring from HFD-fed dams. Lipid metabolism and bile acid secretion synthesis pathways are indicated at the top of the graph. Left panel of the graph represents HH-female offspring while HH-male offspring are presented on the right panel. The shading intensity of the bubble, along with size, is indicative of the Kendall rank correlation coefficient between matrices. Red designates a positive association while blue designates a negative association. Only significant (p-value ≤ 0.05 by Kendall’s test; n = 5–7) correlations are visible in the plot.

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