Figure 8 | Scientific Reports

Figure 8

From: Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice

Figure 8

Sexual dimorphism in BA metabolites and regulatory enzymes and associations with microbial families. (A) mRNA expression of bile acid synthesis related genes Cyp7a1, Cyp8b1, Cyp39a1 and Cyp27a1 in livers of offspring. (B) Associations between Cyp8b1 and Cyp39a1 mRNA levels and bacterial families. (C) Serum concentrations of bile acids TDCA, DCA and CA in offspring. (D) Associations between DCA and TDCA concentrations and bacterial families. Data are expressed as means ± SD. Statistical differences in gene expression were determined using a two-way ANOVA to examine the effects of maternal HF and offspring sex, followed by Student-Newman-Keuls post hoc analyses. (*p < 0.05, **p < 0.01 ***p < 0.001).

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