Figure 3 | Scientific Reports

Figure 3

From: Impact of Escherichia coli K12 and O18:K1 on human platelets: Differential effects on platelet activation, RNAs and proteins

Figure 3

Changes of mRNAs in platelets after exposure to E. coli K12. Analysis with thromboSeq pipeline. (a) Heatmap of platelet mRNA profiles of control (grey) and E. coli K12 co-incubated platelets (green) after three hours incubation in 1:1 platelet-bacteria ratio. (b) Volcano plot of mRNAs of control versus E. coli K12 (1:1) exposed platelets. RNAs of which the concentrations changed significantly after E. coli K12 co-incubation are labelled in red (p < 0.05). (c) Gene ontology (GO) analysis of mRNAs with significantly changed concentrations after E. coli K12 exposure (p < 0.05) using DAVID functional annotation analysis (cluster enrichment score >1). (d) Logarithm 2 fold change (logFC) and normalized counts (norm. counts) of HMBS, ATP2C1 and LRCH4 RNAs in platelets exposed to E. coli K12 bacteria compared to control platelets. Cl., Cluster.

Back to article page