Figure 5
From: Design of metalloproteins and novel protein folds using variational autoencoders
Automated addition of potential metal binding sites to two proteins. The sequence of the SWIB domain of human MDM2 (PDB ID 3LBL) and a sequence generated by the model that is predicted to have high copper-binding character are shown. Highlighted in purple are the residues that form the potential copper binding sites. The sites are shown on the structure of the generated sequence using 3LBL as a template, and compared to 3LBL. The same is shown for a potential site on the link module of human TSG-6 (PDB ID 1O7B) when calcium binding is requested.
