Figure 6
From: Design of metalloproteins and novel protein folds using variational autoencoders
Structures to explore a novel fold. The structure and sequence of 2CU6 are shown. By remodelling the loops at the locations of the blue circles using ModLoop49 a modified structure with a novel topology is generated. This is used as a backbone template to select structures from a pool of ab initio Rosetta structures generated from sequences output by the CVAE. The closest structure to the template is shown.
