Figure 8

Propagation of slow oscillations measured with the two in vivo (A,B) and the in vitro (C) UF-MEA designs. (Aa) Map showing 5 s sample traces recorded by each of the 32 electrodes in the in vivo rectangular UF-MEA (24 electrodes of 50 µm in diameter and 8 of 10 µm). In the blue inset tone can observe the traces of the 10-µm electrodes. Up states are detected perfectly in all channels, including in the 10-µm electrodes. (Ba) Example of traces obtained with the 32-channel in vivo hemispherical UF-MEA. (Bb) Up states initiated in the midline propagating in various directions covered by the UF-MEA. (C) Propagation was also detected with the in vitro UF-MEA. (Ca) Representative Up state traces at different recording sites in the cortical slice (blue points). (Cb) Wave propagation pattern. δ is the mean delay between the detection times of the same wave front at the different pads, it is measured as in Capone et al.³⁶. (Cc) Wave propagation leading area measured as in Capone et al.³⁶.