Figure 1 | Scientific Reports

Figure 1

From: Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration

Figure 1

IVD degeneration timeline. Annular injuries were created in four IVD levels in minipigs to induce disc degeneration (depicted in red). Following this procedure, the animals were randomly divided into 3 groups (3 animals in each group) and imaged at 2, 6, and 10 weeks. At each time point, the animals in one group were sacrificed and the pH within their injured IVDs was measured. The IVDs were harvested for gene expression, histological, and immunohistofluoresence analyses.

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