Figure 2
From: Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration
IVD degeneration following intradiscal puncture. (A) The progress of IVD degeneration at 2, 6, and 10 weeks following intradiscal puncture, as monitored by T2-weighted sagittal MRI. White arrows denote the degenerated IVDs. Quantification of (B) T2, (C) T1, and (D) T1ρ mappings of degenerated IVDs compared to healthy controls at 2, 6, and 10 weeks after puncture (n = 12 per experimental group; *p < 0.05, ****p < 0.0001). (E) Hematoxylin and eosin staining of representative degenerated IVDs 2, 6, and 10 weeks after intradiscal puncture; microphotographs are shown at both low (upper subfigures; scale bars = 1 mm) and high (lower subfigures; scale bars = 100 μm) magnifications.
