Figure 4
From: Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration
Upregulation of pain and inflammatory markers in degenerating IVDs. Quantitative RT-PCR analyses of (A–C) pain-related genes (CGRP, BDKRB1 and COMT) and (D,E) inflammation-related genes (IL-6 and BDNF) harvested from healthy and degenerated IVDs 2, 6, and 10 weeks after intradiscal puncture (n = 3 per group; *p < 0.05, **p < 0.01; RQ, relative quantification, CGRP, calcitonin gene-related peptide, BDKRB1, bradykinin receptor B1, COMT, catechol-Ο-methyltransferase, BDNF, brain-derived neurotrophic factor).
