Figure 1
From: Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14
Kif14 gene expression and proliferation in Kif14 transgenic (Tg) and wild-type (wt) mice. (a) The Kif14 transgene is expressed in all tissues analyzed in Tg mice. (b) Endogenous Kif14 is expressed in all tissues analyzed in wt mice. (c) Mki67 proliferation marker is increased in some Kif14 Tg tissues compared with wt tissues. (d) Mki67 expression positively correlates with Kif14 expression (Spearman’s ρ = 0.21, p = 0.04). All individual samples from all tissue types analyzed are shown (both wt and Tg mice, endogenous Kif14 and Kif14 Tg, respectively). qRT-PCR for the indicated genes, normalized to Hprt and Tbp and reported relative to a pool of all tissues. Mean ± s.d. of results from 3 individual mice shown. Note differences in y-axis scales between panels.
