Table 1 A list of the change of DNA methylation status of fibrosis related genes of db/db mice.
From: Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Gene | DNA Methylation |
|---|---|
Growth Factor | |
Tgfb1 | ↓ |
TgfrII | ↓ |
Ctgf | ↓ |
Ppdgf | ↓ |
Igf-1 | ↓ |
Igf-2 | n.s. |
Igf biding protein 1 | n.s. |
Igf R | n.s. |
Smad 2 | n.s. |
Smad 3 | n.s. |
Glut 1 | ↑ |
Glut 2 | ↑ |
Col IV | n.s. |
Fibronectin | n.s. |
α-sma | n.s. |
Pai-1 | ↓ |
Mmp-2 | ↓ |
Mmp-9 | ↓ |
Vcam-1 | n.s. |
Icam-1 | n.s. |
Reactive oxygen species | |
Nox-1 | ↑ |
Nox-4 | n.s. |
Txnip | ↑ |
Rage | n.s. |
Inflammation | |
p65 | ↓ |
Il-6 | n.s. |
Mcp-1 | n.s. |
Usf1 | ↓ |
Srebp1 | ↓ |
At1a | ↓ |
At1b | ↓ |
