Figure 2

Structural relationships between NOCT and related phosphodiesterases. (A) Structures, sequence identity and function summary for NOCT, PDE12, CNOT6L and TDP2. (B) Active site superposition for NOCT, PDE12, CNOT6L and TDP2. (C) Catalytic residues in the active site of human NOCT. Residues are numbered using human NOCT as a reference. (D) Superposition of the catalytic residues in RNA and DNA hydrolases.