Figure 4

Surface analysis of NOCT and related phosphodiesterases. (A) Vacuum electrostatic potential calculated using Coulomb’s law in SEQMOL-Kd (Methods). (B) Surface area hydrophobic potential calculated using pre-atom desolvation analysis SEQMOL-Kd. The scale of red color (maximum hydrophobicity) in kcal/mol is shown for each protein.