Figure 6

Conservation analysis for NOCT. (A) NOCT conservation calculated from 351 non-redundant protein sequences using SEQMOL-Kd. Multiple sequence alignment was conducted with built-in Muscle 3.714. (B,C) Modified conservation analysis to visualize residues present only in NOCT family members, but absent in the families of PDE12 and CNOT6L deadenylases. Multiple NOCT-specific residues surround the active site.