Figure 10
IL-17−/− mice treated with GalXM present a defect similar to that seen in IL6−/− mice in the control of pulmonary infection. Mice (Wt, IL6−/− and IL17−/−) were intratracheally pretreated with 250 μg/mL capsular GalXM 24 h before an intratracheal injection with 106 C. neoformans cells. After 30 days, the mice were euthanized, and the lungs were recovered. Viable fungal cells were quantified in petri dishes containing agar from the homogenized organ. The results are expressed in CFUs (dilutions: 1:10 for wild type; 1:1000 for IL-6−/− and IL17−/−). The results represent one of four independent experiments (n = 5 mice/group). The asterisk indicates *P < 0.05 relative to the control.
