Table 1 Nerve regeneration after nerve injury and reconstruction with PLLA nerve guide.

From: Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo

 

Autologous nerve graft

Hollow tube

PLLA nerve guide

Nerve guide + cells

p-values (KW)

NF max length (mm)

10.00 (8.98, 10.00)

10.00 (6.04, 10.00)cd

4.14 (1.46, 9.02)ab

3.11 (2.19, 3.94)ab

<0.001

NF average length (mm)

10.00 (8.98, 10.00)

10.00 (6.04, 10.00)cd

3.27 (1.16, 5.61)ab

2.59 (1.88, 3.75)ab

<0.001

ED1 prox (cells/mm2)

44 (20, 68)

 

40 (12, 100)

69 (54, 252)a

0.038

ED1 5 mm dist (cells/mm2)

44 (26, 106)

 

34 (10, 60)ad

88 (6, 194)ac

0.007

S-100 (length in mm)

9.988 (5.753, 1.184)

9.253 (4.851, 15.142)d

9.836 (3.925, 12.865)d

3.905 (2.012, 8.906)abc

0.006

  1. NF, ED1 and S-100 staining of longitudinal sections of the PLLA nerve guide. Values are expressed as median (min, max). KW = Kruskal-Wallis. Statistical significance (p < 0.05) based on the Mann-Whitney U-test is indicated as follows: asignificant difference from autologous nerve graft; bsignificant difference from hollow tube; csignificant difference from PLLA nerve guide; dsignificant difference from PLLA nerve guide + cells.
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