Table 3 Summary of all genes containing mutations in the cutaneous isolates and classification into clusters.
Cluster Number | Cluster Mutation Type | New annotation | Equivalents (when available) |
|---|---|---|---|
Cluster 1 (13) | Nonsense, Frameshift, Insertions, Deletions, IV to VL | LdCL_300021700 | LdBPK_301640 |
LdCL_310020800 | LdBPK_311390 | ||
LdCL_250013200 | LdBPK_250790 | ||
LdCL_310020100 | LdBPK_311320 | ||
LdCL_310022200 | LdBPK_311510 | ||
LdCL_080011700 | LdBPK_080670 | ||
LdCL_340029800 | LdBPK_342210 | ||
LdCL_230014900 | LdBPK_230830 | ||
LdCL_310037100 | LdBPK_312870 | ||
LdCL_220015800 | — | ||
LdCL_140017600 | — | ||
LdCL_230017500 | — | ||
LdCL_310041200 | LdBPK_313290 | ||
Cluster 2 (9) | Multiple SNPs in the same gene, Non-conservative amino acid change in conserved region with good PROVEAN score | LdCL_270015000 | LdBPK_270840 |
LdCL_290026900 | LdBPK_292100 | ||
LdCL_310021600 | LdBPK_311470 | ||
LdCL_310028800 | LdBPK_312080 | ||
LdCL_340046300 | LdBPK_343690 | ||
LdCL_290022800 | LdBPK_291720 | ||
LdCL_310024300 | LdBPK_311710 | ||
LdCL_360006000 | LdBPK_360120 | ||
LdCL_360062000 | LdBPK_365480 | ||
Cluster 3 (18) | Non-conservative amino acid change in conserved region with poor PROVEAN score | LdCL_070018300 | LdBPK_071330 |
LdCL_320013800 | LdBPK_320820 | ||
LdCL_250016900 | LdBPK_251150 | ||
LdCL_220022000 | LdBPK_221470 | ||
LdCL_250015300 | LdBPK_251000 | ||
LdCL_040011100 | LdBPK_040560 | ||
LdCL_360016300 | LdBPK_361120 | ||
LdCL_200014300 | LdBPK_200960 | ||
LdCL_090011700 | LdBPK_090660 | ||
LdCL_130016200 | LdBPK_131090 | ||
LdCL_340009000 | LdBPK_340390 | ||
LdCL_130017800 | LdBPK_131230 | ||
LdCL_230009900 | LdBPK_230440 | ||
LdCL_220018100 | LdBPK_221070 | ||
LdCL_340044900 | LdBPK_343550 | ||
LdCL_290028400 | — | ||
LdCL_250011400 | LdBPK_250620 | ||
LdCL_270014900 | LdBPK_270830 | ||
Cluster 4 (8) | Conservative amino acid change in conserved region with good PROVEAN score | LdCL_350013100 | LdBPK_350830 |
LdCL_360052700 | LdBPK_364550 | ||
LdCL_230026600 | LdBPK_231940 | ||
LdCL_230009400 | LdBPK_230400 | ||
LdCL_320031100 | LdBPK_322560 | ||
LdCL_020008200 | LdBPK_020280 | ||
LdCL_310027700 | LdBPK_311990 | ||
LdCL_320031200 | LdBPK_322570 | ||
Cluster 5 (13) | Conservative amino acid change in conserved region with poor PROVEAN score | LdCL_330011900 | LdBPK_330640 |
LdCL_170010200 | LdBPK_170470 | ||
LdCL_070011900 | LdBPK_070700 | ||
LdCL_210025000 | LdBPK_211930 | ||
LdCL_290022900 | LdBPK_291730 | ||
LdCL_200006300 | LdBPK_200140 | ||
LdCL_290029000 | LdBPK_292290 | ||
LdCL_030007500 | LdBPK_030250 | ||
LdCL_250006200 | LdBPK_250110 | ||
LdCL_360015800 | LdBPK_361070 | ||
LdCL_310023400 | LdBPK_311630 | ||
LdCL_360062700 | LdBPK_365540 | ||
LdCL_140017700 | LdBPK_141190 | ||
Cluster 6 (14) | Non-conservative amino acid change in less conserved region, Conservative amino acid change in less conserved region | LdCL_340022100 | LdBPK_341580 |
LdCL_060011600 | LdBPK_060650 | ||
LdCL_210015400 | LdBPK_211040 | ||
LdCL_050010900 | LdBPK_050580 | ||
LdCL_230011600 | LdBPK_230610 | ||
LdCL_250024100 | LdBPK_251840 | ||
LdCL_070015100 | LdBPK_071060 | ||
LdCL_250005300 | LdBPK_250040 | ||
LdCL_310022100 | LdBPK_311500 | ||
LdCL_200006800 | LdBPK_200200 | ||
LdCL_250014400 | LdBPK_250910 | ||
LdCL_230010400 | LdBPK_230500 | ||
LdCL_120008300 | LdBPK_120275 | ||
LdCL_290028100 | LdBPK_292210 | ||
Cluster 7 (4) | IV-only mutations | LdCL_140010000 | LdBPK_140470 |
LdCL_310035800 | LdBPK_312770 | ||
LdCL_310036400 | LdBPK_312810 | ||
LdCL_320046000 | LdBPK_324000 | ||
LdCL_360021300 | LdBPK_361580 | ||
LdCL_360021400 | LdBPK_361590 | ||
LdCL_360021500 | LdBPK_361600 | ||
LdCL_360021600 | LdBPK_361610 |
