Table 5 Subset of 7 of the identified pharmacogenomic variants (from Table 4) that were also reported in Arab studies as relating to complex disorders.

From: Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics

Pharmaco-genomic variant

Gene

KWT_RAF/1kGP_RAF/GME_RAF 

Ratio KWT_1KGP/Ratio KWT_GME

Ref_risk allele

Drug to which response is reported

Disorder treated with the drug

Disorder with which Arab studies associate the variant

rs1805087

MTR

0.260/0.218/0.202

1.1929/1.2881

A_G

Folic acid; hydroxy-chloroquine; methotrexate; sulfasalazine.

Rheumatoid arthritis

Autism – North Iran97. GG seems to be the risk factor. GG seems to be the risk factor.  Complex trait.

rs1042522

TP53

0.443/0.543/-

0.8150/-

G_C

Cisplatin; paclitaxel

Stomach neoplasms

Susceptibility to Breast Cancer in Tunisia98. Complex trait.

rs1800497

ANKK1

0.1713/0.326/0.191

0.5259/0.8975

G_A

Risperidone

Schizophrenia

Risk of Schizophrenia in Egyptians99. CC and CT genotypes are the risk factors. Complex trait.

rs1801058

GRK4

0.229/0.307/0.292

0.7476/0.7079

T_C

Atenolol

Hypertension

Risk of myocardial infarction among hypertensive subjects in Jordan100. Complex trait.

rs699

AGT

0.583/0.705/0.553

0.8268/1.0535

A_G

Anti-hypertensive

Hypertension

Reduced life-span through genetic susceptibilities to both Essential Hypertension and Myocardial Infarcation in UAE101. Complex trait.

rs1042713

ADRB2

0.551/0.5244/0.565

1.0513/0.98

A_G

Terbutaline

Asthma

Susceptibility to early onset obesity, insulin resistance etc. in Saudi Arabia102. the subjects who carry Gly16 homozygote genotype are in higher risk. Complex trait.

rs1042714

ADRB2

0.225/0.205/0.241

1.0941/0.9312

G_C

Terbutaline

Asthma

Associated with coronary artery disease/myocardial infarction in Saudi Arabia103,104. both the C/G and G/G genotypes are significantly associated with CAD. Complex trait.

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