Figure 1 | Scientific Reports

Figure 1

From: Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis

Figure 1

Global expression profile of miRNAs in the activated lung fibroblasts of multiple lung fibrosis models. (A) Global miRNA-expression profile of fibroblasts from bleomycin- and silica-treated murine lungs on days 7, 14, and 28, as well as those of untreated mice on day 0. The heat map represents the group of differentially expressed miRNAs determined based on the WGCNA and CLICK methods. Each column represents the group and time point, and each row represents an individual miRNA. (B) KEGG pathway enrichment analysis of target genes associated with the miRNA signatures. The enrichment significance of the KEGG pathways was calculated using DIANA-miRPath version 3.0 with Tarbase version 7.0. P-values were calculated for each term using a two-sided hypergeometric test with Benjamini-Hochberg correction. See also Supplemental Tables S3 and S4.

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