Figure 3
SWATH-MS analysis revealed differentially expressed proteins between the wild-type and knockout cell lines. (a) Volcano plot of the p values and fold changes (log2) of the 1646 relatively quantified proteins from the two groups. (b) Heat map analysis of the 466 proteins with significantly altered expression levels. The heat map was produced via Genesis78. All of the significantly altered proteins were grouped into six clusters (labeled as A–F on the right side of the heat map) based on the protein expression patterns. (c) GO analysis of the upregulated proteins in the miR-26a-knockout line, compared to the wild-type line. (d) GO analysis of the downregulated proteins in the miR-26a-knockout line, compared to the wild-type line.
