Table 3 Performance of ADC volumes and PI-RADS in relationship to Gleason Score.

From: Automatic Detection of Prostate Tumor Habitats using Diffusion MRI

Radical prostatectomy

Specificity

Sensitivity

NPV

PPV

AUC

GS 6 vs GS 7–10

VOIHR*

1

0.63

0.722

1

0.8148

VOIIR**

1

0.704

0.765

1

0.8519

VOILR†

0.538

0.889

0.824

0.667

0.6652

GS 6–7 vs GS 8–10

VOIHR*

0.818

1

1

0.529

0.952

VOIIR**

0.818

1

1

0.529

0.9495

VOILR†

0.773

0.778

0.944

0.412

0.7992

Targeted Biopsies

GS 6 vs GS 7–10

VOIHR*

1

0.619

0.467

1

0.7619

VOIIR**

0.857

0.619

0.429

1

0.8636

VOILR†

0.714

0.714

0.455

0.882

0.6463

GS 6–7 vs GS 8–10

VOIHR*

0.818

1

1

0.6

0.8636

VOIIR**

0.727

1

1

0.5

0.8636

VOILR†

0.727

0.667

0.899

0.4

0.7121

PI-RADS (Targeted Biopsies)

GS 6 vs GS 7–10

PI-RADS 3–5

0.286

1

1

0.808

—

PI-RADS 4,5

0.429

0.905

0.6

0.826

—

GS 6–7 vs GS 8–10

PI-RADS 3–5

0.091

1

1

0.231

—

PI-RADS 4,5

0.227

1

1

0.261

—

Template Biopsies

GS 6 vs GS 7–10

VOIHR*

0.866

0.49

0.369

0.927

0.713

VOIIR**

0.743

0.673

0.433

0.866

0.716

VOILR†

0.914

0.404

0.34

0.933

0.663

GS 6–7 vs GS 8–10

VOIHR*

0.826

0.667

0.9

0.513

0.75

VOIIR**

0.844

0.667

0.902

0.541

0.774

VOILR†

0.826

0.667

0.9

0.513

0.74

  1. Abbreviations: ADC = Apparent Diffusion Coefficient; AUC = Area under the curve; GS = Gleason Score; HR = High risk; IR = Intermediate risk; LR = Low risk; NPV = Negative Predictive Value; PPV = Positive Predictive Value; VOI = Volume of Interest.
  2. *ADC < 900 (Peripheral Zone); ADC < 800 (Transition Zone).
  3. **ADC < 1100 (Peripheral Zone); ADC < 850 (Transition Zone).
  4. †ADC < 1300 (Peripheral Zone); ADC < 1050 (Transition Zone).
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