Figure 5
From: Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis
In vivo saliva chloride concentration measurement of cmRNAhCFTR and pDNAhCFTR treated Cftr−/− mice by i.v./ i.t. route (A,B) Functional test of reconstituted CFTR channel and reduced chloride concentration after i.v. (A) or i.t. (B) treatment of Cftr−/− mice compared to untreated Cftr−/− (black), positive controls (violet), and percentages relative to the positive control; n = 4 mice per group; two mock controls were included (white); boxes represent the means ± minimum and maximum values. The blue area represents the variance of the negative controls which are biological replicates. *P ≤ 0.05; **P ≤ 0.01 versus untreated Cftr−/− mice.
