Figure 5
Compound transcription signature clustering. Transcriptomes of drug-treated asexual parasites33 and parasites undergoing amino acid starvation16 (turquoise circle, Starve) were separated with a support vector machine (SVM) classifier and subsequently clustered in order to establish relatedness of chemical perturbations to cell cycle-arrested parasites (2 mM DFMO-treated, 24 h, orange circle). Q = quinine, CQ = chloroquine, Stau = straurosporine, Rosc = roscovitine, Api = apicidine, Febr = febrifugine, Art = artemisinin, leu = leupeptine, Tri = trichostatin A, Col = colchicine, Cycl = cyclosporine.
