Table 1 Matched cell cycle related orthologues of P. falciparum and yeast transcriptomes perturbed in cell cycle arrest and re-initiation. P. falciparum parasite transcripts were matched to cell cycle associated transcripts from non-quiescent and quiescent yeast transcriptomes37,38 (www.yeastgenome.org).
PlasmoDB code | Plasmodium gene description | Yeast orthologue | Yeast gene description |
|---|---|---|---|
G 0 (7/14 orthologues in arrested dataset) | |||
pf3d7_1003300 | N-acetyltransferase, putative | YHR013C | N-terminal acetyltransferase A (ARD1) |
pf3d7_1427800 | Exosome complex exonuclease RRP41, putative (RRP41) | YGR195W | Exosome complex component SKI6 |
pf3d7_1020700 | Histone acetyltransferase, putative | YNL132W | 18 S rRNA cytosine acetyltransferase |
pf3d7_1143300 | DNA-directed RNA polymerases I and III subunit RPAC1, putative | YPR110C | RPAC1 |
G 1 -phase (44/95 orthologues in arrested dataset) | |||
— | Ribosomal subunits (11) | — | Ribosomal subunits |
pf3d7_0315100 | Translation initiation factor 4E (eif4e) | YOL139C | eIF4E |
pf3d7_1468700 | Eukaryotic initiation factor 4 A (eif4a) | YJL138C | eIF4A |
pf3d7_0933200 | Calcyclin binding protein, putative | YOR057W | Suppressor of G2 allele of SKP1 (SGT1) |
pf3d7_1342700 | Transcription activator, putative | YHR143W | Daughter-specific expression protein 2 (DSE2) |
G 1 /S phase (4/11 orthologues in re-initiated dataset) | |||
pf3d7_0705300 | Origin recognition complex subunit 2, putative (ORC2) | YBR060C | Origin recognition complex subunit 2 |
pf3d7_1355100 | DNA replication licensing factor MCM6 (MCM6) | YGL201C | DNA replication licensing factor MCM6 |
pf3d7_0527000 | DNA replication licensing factor MCM3, putative (MCM3) | YEL032W | DNA replication licensing factor MCM3 |
pf3d7_1317100 | DNA replication licensing factor MCM4 (MCM4) | YPR019W | DNA replication licensing factor MCM4 |
S phase (8/21 orthologues in re-initiated dataset) | |||
pf3d7_1319700 | Protein phosphatase PP2A regulatory subunit A, putative | YAL016W | Protein phosphatase PP2A regulatory subunit A |
pf3d7_1241700 | Replication factor C subunit 4, putative | YOL094C | Replication factor C subunit 4 |
pf3d7_1361900 | Proliferating cell nuclear antigen (PCNA) | YBR088C | Proliferating cell nuclear antigen (PCNA) |
pf3d7_0630300 | DNA polymerase epsilon, catalytic subunit a, putative | YNL262W | DNA polymerase epsilon catalytic subunit A |
pf3d7_1414400 | Serine/threonine protein phosphatase PP1 (PP1) | YER133W | Serine/threonine-protein phosphatase PP1–2 |
pf3d7_1211700 | DNA replication licensing factor MCM5, putative (MCM5) | YLR274W | Minichromosome maintenance protein 5 (MCM5) |
pf3d7_0411900 | DNA polymerase alpha | YNL102W | DNA polymerase alpha catalytic subunit A |
pf3d7_0910900 | DNA primase large subunit, putative | YKL045W | DNA primase large subunit |
pf3d7_1437200 | Ribonucleoside-diphosphate reductase, large subunit, putative | YER070W | Ribonucleoside-diphosphate reductase large chain 1 |
G 2 /M phase (8/24 orthologues in re-initiated dataset) | |||
pf3d7_0624500 | Anaphase promoting complex subunit, putative | YDL008W | Anaphase-promoting complex subunit 11 |
pf3d7_0714000 | Histone H2B variant (H2B.Z) | YDR224C | Histone H2B.1 |
pf3d7_1027700 | Centrin-3 (CEN3) | YOR257W | Cell division control protein 31 (CDC31) |
pf3d7_0320900 | Histone H2A variant, putative (H2A.Z) | YOL012C | Histone H2A.Z |
