Figure 2

Pharmacological validation of the SPM. (a) Changes in spatio-temporal patterns of behaviour in response to buspirone treatment. *Significant difference from time percentage spent in deep arms, #significant interaction between treatment and area. (b–d) Changes in arm preference-associated variables and velocity in response to buspirone. (e–g) Effects of chlordiazepoxide. (h–j) Effects of caffeine. *Significant difference from vehicle treated group. Dashed lines represent polynomial trendlines.