Table 4 Univariate linear mixed model analyses between the absolute variation of aqueous cytokines levels and anatomical and functional parameters.

From: Relationship between aqueous humor cytokine level changes and retinal vascular changes after intravitreal aflibercept for diabetic macular edema

Absolute variation of cytokine levels (pg/mL)

Absolute variation of anatomical and functional parameters

BCVA (logMAR)

CMT (µm)

Parafoveal SCPD (µm)

b(SE)

p-value

b(SE)

p-value

b(SE)

p-value

IL-1β

−0.250 (0.21)

0.239

0.505 (0.34)

0.136

−0.890 (0.08)

0.001

IL-1RA

0.455 (0.19)

0.025

0.526 (0.26)

0.118

−0.127 (0.14)

0.726

IL-5

0.209 (0.10)

0.326

0.207 (0.26)

0.567

0.760 (0.21)

0.010

IL-6

−0.244 (0.21)

0.251

−0.177 (0.56)

0.624

0.483 (0.19)

0.017

IL-12p40

0.140 (0.18)

0.515

0.065 (0.27)

0.858

0.146 (0.05)

0.686

IL-12p70

0.169 (0.22)

0.430

0.729 (0.21)

0.017

−0.055 (0.14)

0.880

VEGF

−0.420 (0.20)

0.041

0.637 (0.31)

0.047

−0.729 (0.10)

0.017

EOTAXIN

0.305 (0.10)

0.147

0.383 (0.22)

0.274

−0.395 (0.17)

0.258

GRO

−0.105 (0.21)

0.625

0.809 (0.25)

0.005

−0.298 (0.18)

0.402

IP-10

−0.048 (0.28)

0.824

0.718 (0.21)

0.019

−0.940 (0.30)

<0.001

Fracktalkine

−0.143 (0.22)

0.505

0.900 (0.66)

<0.001

−0.529 (0.58)

0.116

FLT-3L

0.027 (0.01)

0.901

0.449 (0.39)

0.193

0.069 (0.14)

0.849

  1. Abbreviations: BCVA = best corrected visual acuity, CMT = central macular thickness; SCPD = superior capillary plexus density; b = regression coefficient adjusted for age, gender and duration of diabetes; SE = standard error.
  2. Bolded p-value were significant after FDR correction.