Table 2 Effect of pretreatment of CurNisNp on markers of oxidative stress in MI induced guinea pigs.

From: Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs

 

Group A

Group B

Group C

Group D

Group E

Hydrogen peroxide (μmol/min mg protein)

Heart

38.35 ± 2.29

41.73 ± 4.41a

37.98 ± 1.61b

36.54 ± 2.14b

37.04 ± 2.27b

Kidney

42.06 ± 7.48

60.48 ± 5.76a++

44.39 ± 6.48b++

43.25 ± 7.10b++

38.50 ± 2.71b++

Malondialdehyde (μmol/g tissue)

Heart

0.65 ± 0.03

0.78 ± 0.06a++

0.55 ± 0.03a+,b++

0.55 ± 0.03a+,b++

0.18 ± 0.01a++,b++

Kidney

0.50 ± 0.06

0.73 ± 0.19a

0.71 ± 0.19a

0.59 ± 0.10b

0.74 ± 0.04a

Total thiol (nmole/mg protein)

Heart

56.68 ± 11.70

54.33 ± 6.87

60.14 ± 7.94

57.41 ± 9.34

53.01 ± 11.09

Kidney

41.46 ± 8.41

33.74 ± 3.69a

34.64 ± 5.32a

31.81 ± 3.41a

48.71 ± 7.99b+

Non-protein thiol (nmole/mg protein)

Heart

8.43 ± 3.22

9.58 ± 1.64

12.82 ± 1.52a,b+

10.54 ± 2.48

15.93 ± 0.21a,b

Kidney

20.74 ± 5.87

15.72 ± 1.36a

31.20 ± 10.23a,b++

15.00 ± 4.53a

21.51 ± 6.058b

  1. Note; results in the table above are in Mean ± standard deviation of each group of five guinea pigs. aP < 0.05 compared with group A; a+P < 0.01 compared with group A; a++P < 0.001 compared with group A; bP < 0.05 compared with group B; b+P < 0.01 compared with group B; b++P < 0.001 compared with group B.