Table 2 Biochemical data of all groups.
Groups | db/m | db/db | Metformin (0.196 g/kg) | SWJH (0.978 g/kg) | SWJH (1.957 g/kg) | SWJH (3.914 g/kg) | Berberine (0.157 g/kg) |
|---|---|---|---|---|---|---|---|
Body weight (g) | 25.2 ± 1.00** | 60.7 ± 3.50 | 58.9 ± 5.70 | 57.6 ± 2.43 | 53.3 ± 2.10** | 56.0 ± 2.80* | 56.5 ± 3.00* |
Left kidney weight (g) | 0.17 ± 0.01** | 0.22 ± 0.01 | 0.18 ± 0.02** | 0.18 ± 0.03* | 0.18 ± 0.01** | 0.18 ± 0.02** | 0.18 ± 0.01** |
FBG (mmol/L) | 6.0 ± 0.60** | 26.5 ± 1.90 | 17.9 ± 3.10** | 23.9 ± 4.00 | 18.9 ± 5.80* | 17.2 ± 7.90* | 17 ± 2.10** |
BUN (mmol/L) | 4.6 ± 0.40** | 7.4 ± 1.1 | 6.1 ± 0.7* | 5.1 ± 0.4** | 4.6 ± 1.1** | 5.0 ± 0.7** | 4.7 ± 0.7** |
UAE (mg/day) | 0.64 ± 0.04** | 5.04 ± 1.26 | 1.40 ± 0.73** | 1.69 ± 0.67** | 1.14 ± 0.45** | 0.78 ± 0.12** | 0.60 ± 0.33** |
UMAlb (µg/day) | 9.5 ± 1.7** | 63.6 ± 25.4 | 28.6 ± 16.7* | 20.9 ± 9.3** | 33.1 ± 20.4* | 18.8 ± 9.8** | 16.9 ± 3.8** |
Scr (µmol/L) | 63.0 ± 5.9** | 147.8 ± 14.2 | 119.1 ± 5.0** | 124.4 ± 20.0* | 115.2 ± 7.6** | 118.9 ± 17.3* | 64.3 ± 14.8** |
UA(µmol/L) | 66.3 ± 13.1** | 152.6 ± 41.1 | 75.9 ± 14.7** | 73.7 ± 31.6** | 101.2 ± 24.7* | 109.3 ± 43.9 | 96.6 ± 15.7* |
TGF-β1 (×1000 pg/ml) | 6.2 ± 3.0** | 16.6 ± 5.8 | 6.5 ± 3.0** | 4.7 ± 0.9** | 5.4 ± 0.8** | 7.8 ± 3.0* | 5.3 ± 1.1** |
VEGF (pg/ml) | 184.5 ± 17.2* | 205.7 ± 5.9 | 212.0 ± 22.8 | 179.2 ± 28.8 | 224.7 ± 25.7 | 197.1 ± 34.1 | 188.1 ± 17.3* |
