Figure 2

Plasma metabolic characterization of response to 12 months’ cART. Modified volcano plots showing (a) the biogenic amine profile, and (b) the lipid profile. The modified volcano plots are representative of the −log10(FDR adjusted paired t-test p-value) on the y-axis with the x-axis showing the scaled mean of the paired differences per metabolite, between the baseline and 12 months cART follow-up sample (patient population B). The horizontal dashed line represents a false discovery rate adjusted q-value < 0.05. Significant metabolites are identifiable by coloured symbols with either a name or corresponding class colour identifier. CE – Cholesterol esters; LPC – Lysophosphatidylcholines; PC – Phosphatidylcholines; PC-O - Plasmalogen PCs; PE – Phosphatidylethanolamines; PE-O – Plasmalogens PEs; SM – Sphingomyelins.