Figure 3
Immune-metabolic networks of controls, untreated HIV and the influence of cART. (a) Control immune-metabolic correlation network based on correlating the absolute levels of plasma metabolites and plasma cytokines in the control group. (b) Untreated HIV immune-metabolic correlation network based on correlating the absolute levels of plasma metabolites and plasma cytokines in the untreated HIV group (Population B). (c) The immune-metabolic correlation network following 12 months cART. Using the paired samples of population B, the relative change in levels of 12 months’ cART compared to their baseline levels (untreated HIV sample) were determined for plasma metabolites and cytokines and subsequently correlated. For all three networks, spearman correlations were performed and significant correlations were defined as having a strict p-value (two-tailed) < 0.01.
