Figure 8 | Scientific Reports

Figure 8

From: Downregulation of intratumoral expression of miR-205, miR-200c and miR-125b in primary human cutaneous melanomas predicts shorter survival

Figure 8

miR-205 overexpression and miR-205 inhibition functional effects on human melanoma cells. (A) No effect on proliferation was observed between miR-205 overexpressing A375 cells versus scrambled/control cells. Data represent the mean ± SD of 4 independent experiments. (B) A representative microscopic image of crystal violet staining of the migration and invasion assays in miR-205 overexpressing A375 cells and control cells. (C and D) Transwell migration (n = 3) and matrigel invasion (n = 3) assays on A375 cells. A375 cells transduced with miR-205 had higher migratory but lower invasive potentials than the control cells. (E and F) Transwell migration (n = 3) and matrigel invasion (n = 3) assays on A375 cells transfected with miR-205 inhibition negative control and miR-205-5p inhibitor. miR-205 inhibited cells migrated less but had higher invasive ability. Data represent the mean ± SD of 3 independent experiments. **p < 0.01, *p < 0.05.

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