Table 3 Results of the discriminant analysis using the CSF biomarker levels for a differential diagnosis of PD from normal controls.
Sensitivity (95% CI) | Specificity (95% CI) | AUC (95% CI) | cut-off value | |
|---|---|---|---|---|
LC3B | 96.9% (83.8–99.9) | 89.3% (71.8–97.7) | 0.982 (0.959–1.000) | 29.8 pg/mL |
Beclin1 | 96.9% (83.8–99.9) | 71.4% (51.3–86.8) | 0.869 (0.765–0.974) | 0.26 ng/mL |
ATG5 | 56.3% (37.7–73.6) | 82.1% (63.1–93.9) | 0.697 (0.697–0.833) | 0.64 AU |
LAMP-2 | 62.5% (43.7–78.9) | 75.0% (55.1–89.3) | 0.663 (0.520–0.806) | 0.31 pg/mL |
α-synuclein | 96.9% (83.8–99.9) | 53.6% (33.9–72.5) | 0.828 (0.724–0.931) | 174.5 pg/mL |
Total tau | 34.4% (18.6–53.2) | 100.0% (100.0–100.0) | 0.691 (0.557–0.825) | 38.57 pg/mL |
