Figure 3 | Scientific Reports

Figure 3

From: Impact of preanalytical conditions on plasma concentration and size distribution of extracellular vesicles using Nanoparticle Tracking Analysis

Figure 3

Visualization of Extracellular Vesicles (EVs) by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). (Panel A) EVs with phospholipid bilayer membrane after ultra-thin sectioning of the Epon blocks. (Panel B) Representative transmission electron micrograph of purified, negatively stained annexin positive and negative bilayer membrane extracellular vesicles. (Panel C) Representative transmission electron micrograph of plasma purified, negatively stained EVs. (Panel D) Representative micrograph of an EV by SEM, isolated from EDTA peripheral blood of a healthy donor at the working distance of 2.6 mm and an accelerating voltage of 2.00 kV (Original magnification 61.12 KX). EVs were spherical and presented uneven non-smooth surfaces.

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