Figure 3 | Scientific Reports

Figure 3

From: High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer

Figure 3

Ganetespib perturbs central PrCa signaling pathways in mouse and human cell lines. Western blots of extracts from cell lines as indicated were probed for signaling proteins. (A) PCAP-1 and PCAP-5 mouse cell lines were exposed to DMSO or 125 nM ganetespib (G) for 24 and 48 hours. (B) Human LAPC4 and LNCaP cells were treated with DMSO or 125 nM ganetespib (G) for 24 or 48 hours. Western blots are representative of three separate experiments and separate gels are outlined in black.

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