Figure 2
From: Phylogenetic and mutational analyses of human LEUTX, a homeobox gene implicated in embryogenesis
Phylogenetic tree of Leutx protein sequences of eutherian species, and variation of the specificity determining residues. The phylogenetic tree was constructed using Neighbour joining (see Materials and Methods). Three Crx homeodomain sequences (bottom) were used as outgroup, since the Leutx gene is likely derived from a Crx gene22. Right panel: Alignment of amino acid sequences in the recognition helix, spanning residues 47 to 55 of homeodomain (54 to 62 of human LEUTX). Consensus (bottom right) is set at the 90% level, and the notation is based on MView83 with “*” indicating the specificity determining residues. “#” indicates position 47 and 54 of the homeodomain (see also Fig. 1).
