Table 2 ApoE genotype and allele frequency proportions in percent (95% confidence interval) among unrelated HCHS/SOL participants by genetic ancestry group.

From: Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)

 

Central American

Cuban

Dominican

Mexican

Puerto Rican

South American

P-value (χ2)

N = 931

N = 1679

N = 725

N = 2900

N = 1416

N = 612

Genotype

E22

0.32(0.01; 0.69)

0.48(0.15; 0.81)

0.69(0.09; 1.29)

0.1(0.01; 0.22)

0.35(0.04; 0.66)

0

 

E23

6.02(4.49; 7.54)

10.9(9.41; 12.39)

12.83(10.39; 15.26)

5.07(4.27; 5.87)

8.04(6.62; 9.45)

6.37(4.44; 8.31)

 

E24

1.07(0.41; 1.74)

1.13(0.63; 1.64)

3.03(1.79; 4.28)

0.45(0.21; 0.69)

1.69(1.02; 2.36)

0.82(0.01; 1.53)

 

E33

72.93(70.08; 75.76)

65.52(63.24; 67.79)

55.17(51.55; 58.79)

74.1(72.51; 75.70)

66.57(64.12; 69.03)

73.37(69.86; 76.87)

 

E34

18.47(15.98; 20.87)

19.95(18.04; 21.86)

24.69(21.55; 27.83)

19.03(17.61; 20.46)

21.72(19.57; 23.87)

17.32(14.32; 20.32)

 

E44

1.18(0.49; 1.88)

2.03(1.35; 2.70)

3.59(2.23; 4.94)

1.24(0.84; 1.64)

1.62(0.96; 2.28)

2.12(0.98; 3.27)

<0.0001

Allele

E2

3.87(2.99, 4.74)

6.49(5.66, 7.33)

8.62(7.18, 10.07)

2.86(2.43, 3.29)

5.22(4.40, 6.04)

3.59(2.55, 4.64)

 

E3

85.18(83.56, 86.79)

80.94(79.61, 82.27)

73.93(71.67, 76.19)

86.16(85.27, 87.03)

81.45(80.02, 82.88)

85.21(83.22, 87.20)

 

E4

10.96(9.57, 12.46)

12.57(11.45, 13.69)

17.45(15.49, 19.40)

10.98(10.18, 11.79)

13.33(12.08, 14.58)

11.19(9.43, 12.96)

<0.0001

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