Figure 5 | Scientific Reports

Figure 5

From: Disulfiram and BKM120 in Combination with Chemotherapy Impede Tumor Progression and Delay Tumor Recurrence in Tumor Initiating Cell-Rich TNBC

Figure 5

DSF/Cu and BKM120 induce apoptosis in corresponding TIC populations. (A) The FACS analysis of apoptotic cells with or without DSF/Cu mixture treatment (0.75 µM) in ALDH+ and ALDH- population in SUM102 cells. (B) DSF/Cu mixture treatment in SUM102 cells led to more profound apoptosis in the ALDH+ population compared to the ALDH- population (*P < 0.05). (C) The FACS analysis of apoptotic cells with or without BKM120 treatment (10 µM) in CD44+ and CD44− population in MDA-MB231 cells. (D) BKM120 treatment (10 µM) in MDA-MB231 cells led to more profound apoptosis in the CD44+ TIC population compared to the CD44− population (**P < 0.01). (E) The FACS analysis of apoptotic cells with or without PAC treatment in ALDH+ and ALDH− population in SUM102 cells. (F) Summary of the FACS assay results showed no significant change of apoptosis between ALDH+ and ALDH− cell population after PAC treatment. (G) The FACS analysis of apoptotic cells with or without PAC treatment in CD44+ and CD44− population in MDA-MB231 cells. (H) Summary of the FACS assay results showed no significant change of apoptosis between CD44+ and CD44− cell populations after PAC treatment.

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